Role of Hypoxia-inducible Factor-1 Alpha in Neural Stem/progenitor Cell Function following Hypoxia By
نویسندگان
چکیده
OF DISSERTATION Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Biomedical Sciences The University of New Mexico Albuquerque, New Mexico
منابع مشابه
Defining the Role of Oxygen Tension in Human Neural Progenitor Fate
Hypoxia augments human embryonic stem cell (hESC) self-renewal via hypoxia-inducible factor 2α-activated OCT4 transcription. Hypoxia also increases the efficiency of reprogramming differentiated cells to a pluripotent-like state. Combined, these findings suggest that low O2 tension would impair the purposeful differentiation of pluripotent stem cells. Here, we show that low O2 tension and hypox...
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